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To examine whether TZP could prevent the onset of liver fibrosis development, C57BL/6J mice were fed CD or HFD with concurrent treatment of TZP (Selleck Chemicals, P1206, subcutaneous injection, 30 nmol/kg) or vehicle (20 mM Tris-HCl, 0.05% Tween-80, pH 8.0) every 3 days for 10 weeks
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