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For example, in human macrophages, the GLP-1/GLP-1R axis induces anti-inflammatory M2 macrophage phenotype, such as induction of IL-10, CD163, CD204 and arginase 1 (Arg1) (figure 3) and downregulation of iNOS expression as indicated by signal transducer and activator 3 (STAT3) activation and overexpression [178–180]